Discussion:
Mucinex Sucks
(too old to reply)
Steven Litvintchouk
2004-02-07 15:13:07 UTC
Permalink
For years I was taking prescription-strength (600 mg) guaifenisin
caplets and they seemed to help thin my mucus and make my coughing more
productive. It was in generic form under such names as Humibid LA and
Q-Bid, and you needed a prescription.

But somehow, Adams Laboratories recently got the FDA to give them an
exclusive right to sell this med, which they call Mucinex. The good
news is that it no longer needs a prescription. The bad news is that
all the other manufacturers of prescription-strength guaifenisin were
forced to take theirs off the market--no more Humibid LA or Q-BID.
Granting an exclusive monopoly to Adams to sell a med that has been
around since before I was born inevitably is going to make it more
expensive and harder to come by than if you had a choice of
manufacturers. Several times I've stopped by drugstores and been told
that they ran out of it.

Getting an exclusive right to sell a med that has been in generic form
for years, from a variety of manufacturers, really sucks.



-- Steven L.
M
2004-02-07 15:59:39 UTC
Permalink
Two months now---I have to agree 100%

I'm fighting a chest cold right now--boy would
I love to have a few "real" humibids !!!

Maureen
Post by Steven Litvintchouk
For years I was taking prescription-strength (600 mg) guaifenisin
caplets and they seemed to help thin my mucus and make my coughing more
productive. It was in generic form under such names as Humibid LA and
Q-Bid, and you needed a prescription.
But somehow, Adams Laboratories recently got the FDA to give them an
exclusive right to sell this med, which they call Mucinex. The good
news is that it no longer needs a prescription. The bad news is that
all the other manufacturers of prescription-strength guaifenisin were
forced to take theirs off the market--no more Humibid LA or Q-BID.
Granting an exclusive monopoly to Adams to sell a med that has been
around since before I was born inevitably is going to make it more
expensive and harder to come by than if you had a choice of
manufacturers. Several times I've stopped by drugstores and been told
that they ran out of it.
Getting an exclusive right to sell a med that has been in generic form
for years, from a variety of manufacturers, really sucks.
-- Steven L.
DreamHarp7
2004-02-07 17:47:05 UTC
Permalink
Post by Steven Litvintchouk
The bad news is that
all the other manufacturers of prescription-strength guaifenisin were
forced to take theirs off the market--no more Humibid LA or Q-BID.
I now get my Guaifenesin (LA) from a
compounding pharmacy. They a make
a 10% topical gel also of Guai. The
Mucinex does not work for me- for
congestion. I thought Guai. is
Guai. Also,if you need a dye free
Guai. you can get a special RX
written up and some insurance com-
panies will pay for it dye free. The
Guai is very expensive now. I heard the
FDA gets a percentage of this.
An interesting note : Many people
around the world are taking Guai-
fenesin for a fibromyalgia protocol
and some are reporting they are
getting symptom free from the Guai.
Many Fibro. groups are writing the
FDA, & Adams Lab about this
exclusive monopoly and jaking up the
price!
Ron
2004-02-07 19:21:22 UTC
Permalink
Post by Steven Litvintchouk
Getting an exclusive right to sell a med that has been in generic form
for years, from a variety of manufacturers, really sucks.
Welcome to the Bush administration.
knob
2004-02-09 02:11:57 UTC
Permalink
Post by Ron
Post by Steven Litvintchouk
Getting an exclusive right to sell a med that has been in generic form
for years, from a variety of manufacturers, really sucks.
Welcome to the Bush administration.
Sorry it has nothing do with Bush. Anyone who can get approval
can sell it.
Don Brady
2004-02-09 02:53:37 UTC
Permalink
Post by knob
Sorry it has nothing do with Bush. Anyone who can get approval
can sell it.
We probably shouldn't get involved in party politics here alright.

But I wonder what made the Mucninex people so sure in their press release that
they would have no competition in this lucrative market? There must be
significant barriers to getting approval.
knob
2004-02-09 04:21:28 UTC
Permalink
Post by Don Brady
Post by knob
Sorry it has nothing do with Bush. Anyone who can get approval
can sell it.
We probably shouldn't get involved in party politics here alright.
But I wonder what made the Mucninex people so sure in their press release that
they would have no competition in this lucrative market? There must be
significant barriers to getting approval.
There sure is. It's just like getting any new drug approved.
Part of their press release is marketing talk but it may
be likely that no one else has expressed any interest in
getting approved for it.
CBI
2004-02-12 02:02:45 UTC
Permalink
Post by knob
Post by Don Brady
But I wonder what made the Mucninex people so sure in
their press
Post by knob
Post by Don Brady
release that they would have no competition in this
lucrative
Post by knob
Post by Don Brady
market? There must be significant barriers to getting
approval.
Post by knob
There sure is. It's just like getting any new drug
approved.
Post by knob
Part of their press release is marketing talk but it may
be likely that no one else has expressed any interest in
getting approved for it.
Also - it takes time. So if no one else is close to being
approved they know they have a monopoly for at least a
while. If it turns out to be very lucrative you know others
will eventually horn in.
--
CBI, MD
CBI
2004-02-07 21:28:00 UTC
Permalink
Post by Steven Litvintchouk
But somehow, Adams Laboratories recently got the FDA to
give them an
Post by Steven Litvintchouk
exclusive right to sell this med, which they call Mucinex.
Is this true? Mucinex is the only "prescription strength"
guaifenisen that I know of but I had assumed that it was
just becasue the others had stopped making it. I hadn't
heard that the FDA had given any kind of exclusivity rights
to the manufacturer or forced theothers out and wouldn't
think it would be legal (but have been wrong abou that kind
of assumption before).
--
CBI, MD
Don Brady
2004-02-07 21:39:16 UTC
Permalink
Here is some background:

http://www.biospace.com/news_story.cfm?StoryID=9371420&full=1
Don Brady
2004-02-07 21:50:49 UTC
Permalink
This one is more up to date:

http://www.af-pharmacists.org/safp/publications/recalls/mmqc_02_1351.htm
or

http://www.adamslaboratories.com/PRESS%20RELEASE%2010-21-02.pdf

Note the sentence:

"the FDA issued warning letters on October 11, 2002, deeming all extended
release guaifenesin tablets without an approved abbreviated new drug
application (ANDA) or NDA illegal and misbranded."


==================================================================

Adams Respiratory Therapeutics ANNOUNCES FDA APPROVAL OF NDA FOR 1200 mg
MUCINEX™ TABLET
- FDA Action Marks Company’s Second Product Approval for Long-Acting
Guaifenesin -

Fort Worth, TX – January 21, 2003 – Adams Respiratory Therapeutics, Inc., a
provider of specialty pharmaceuticals for respiratory care, today announced it
has received approval from the U.S. Food and Drug Administration (FDA) for its
new drug application (NDA) for the 1200 mg strength tablet of Mucinex™, a
single-entity, long-acting guaifenesin product that will be available without a
prescription. Mucinex™ provides the maximum therapeutic daily dosage of
guaifenesin for adults by taking one 1200 mg tablet, or two 600 mg tablets,
every 12 hours. It is indicated to help loosen phlegm (mucus) and thin
bronchial secretions to rid the bronchial passageways of bothersome mucus and
make coughs more productive.



The FDA approval of Mucinex™ 1200 mg is Adams Laboratories’ second product
approval in six months. In July of last year, the FDA approved the company’s
NDA for the Mucinex™ 600 mg tablet - the first long-acting guaifenesin product
to have an NDA approved by the FDA. As a result of the Durham-Humphrey
Amendment of 1951 to the Federal Food, Drug, and Cosmetic Act which stipulates
that a drug product cannot be marketed simultaneously both as a prescription
and as a nonprescription product at the same strength and same dosage and for
the same indication, the FDA issued warning letters on October 11, 2002,
deeming all extended release guaifenesin tablets without an approved
abbreviated new drug application (ANDA) or NDA illegal and misbranded.





John Q. Adams Sr., Chairman and Chief Executive Officer, stated, “The FDA
approval of our Mucinex™ 1200 mg tablet marks Adams Respiratory Therapeutics’
second major drug approval in the past several months, and demonstrates the
company’s ability to leverage our unique regulatory strategy and proprietary
technology to build a strong pipeline of respiratory products. Our large,
knowledgeable sales force will continue to aggressively market both the 600 mg
and 1200 mg Mucinex™ tablets to physicians and pharmacists in order to capture
as much of the $3.2 billion cough, cold and flu market as possible. In
addition, we will continue to expand our respiratory franchise with NDA
submissions for Mucinex™ combination products this year.”



Mucinex™ is available “behind the counter” from pharmacists nationwide, with or
without a physician’s recommendation. It works by loosening phlegm (mucus) and
thinning bronchial secretions to rid the bronchial passageways of bothersome
mucus – making coughs more productive. Mucinex™ combines extended-release and
immediate-release features in a single tablet.



ABOUT Adams Respiratory Therapeutics:

Based in Fort Worth, Texas, Adams Respiratory Therapeutics develops, markets
and sells prescription and non-prescription pharmaceuticals for the treatment
of respiratory disorders and diseases. In addition to Mucinex™, the Adams
Respiratory Therapeutics product portfolio includes the Aquatab® line of
guaifenesin-based cough and cold products and the ALLERx™ line of products to
treat allergic rhinitis. Adams Laboratories seeks to become the leading
specialty provider of pharmaceuticals for the treatment of a broad range of
respiratory diseases via a business development strategy that combines product
development, acquisitions and in-licensing tactics. More information can be
found on the company’s website at www.adamslaboratories.com.


--------------------------------------------------------------------------------
CBI
2004-02-07 23:32:36 UTC
Permalink
http://www.af-pharmacists.org/safp/publications/recalls/mmqc_02_1351.htm
Post by Don Brady
or
http://www.adamslaboratories.com/PRESS%20RELEASE%2010-21-02.pdf
Post by Don Brady
"the FDA issued warning letters on October 11, 2002,
deeming all
Post by Don Brady
extended release guaifenesin tablets without an approved
abbreviated
Post by Don Brady
new drug application (ANDA) or NDA illegal and
misbranded."


I thought it was something lihe this. The FDA has recently
been going back and taking another look at older drugs. What
they do is ask that the drug companies submit updated
information - basically go through a mini version of the
application process. So it is not that they gave Adams labs
any kind of exclusivity deal. It is just that all the other
companies decided not to go through the expense of being
evaluated.
--
CBI, MD
Steven Litvintchouk
2004-02-08 01:26:13 UTC
Permalink
Post by Don Brady
http://www.af-pharmacists.org/safp/publications/recalls/mmqc_02_1351.htm
Post by Don Brady
or
http://www.adamslaboratories.com/PRESS%20RELEASE%2010-21-02.pdf
Post by Don Brady
"the FDA issued warning letters on October 11, 2002,
deeming all
Post by Don Brady
extended release guaifenesin tablets without an approved
abbreviated
Post by Don Brady
new drug application (ANDA) or NDA illegal and
misbranded."
I thought it was something lihe this. The FDA has recently
been going back and taking another look at older drugs. What
they do is ask that the drug companies submit updated
information - basically go through a mini version of the
application process. So it is not that they gave Adams labs
any kind of exclusivity deal. It is just that all the other
companies decided not to go through the expense of being
evaluated.
Implying that if no manufacturer had been willing to defend the safety
and efficacy of guaifenisin, the FDA would have taken it off the market
altogether?

Robins is lucky that Adams did the leg work or else Robitussin would
have gone bye-bye.


-- Steven L.
CBI
2004-02-09 21:23:39 UTC
Permalink
Post by Steven Litvintchouk
Post by CBI
I thought it was something lihe this. The FDA has recently
been going back and taking another look at older drugs. What
they do is ask that the drug companies submit updated
information - basically go through a mini version of the
application process. So it is not that they gave Adams labs
any kind of exclusivity deal. It is just that all the other
companies decided not to go through the expense of being
evaluated.
Implying that if no manufacturer had been willing to defend the safety
and efficacy of guaifenisin, the FDA would have taken it off the market
altogether?
Robins is lucky that Adams did the leg work or else Robitussin would
have gone bye-bye.
No, just the higher dose extended release tablets that were being sold
by prescription would have gone bye-bye. Presumably the lower dose OTC
syrups would have been OK.
--
CBI, MD
ENTconsult
2004-02-11 05:49:45 UTC
Permalink
Implying that if no manufacturer had been willing to defend the safety
Post by Steven Litvintchouk
and efficacy of guaifenisin, the FDA would have taken it off the market
altogether?
that is correct. Once a product is off patent, if the FDA requires a new drug
application then the company is faced with the following dilema:.
If they do the NDA it will cost + 100,000 just to file the application. then
the additional hundreds of thousands. Then, if the FDA requires clinical
studies, we are speaking of millions. If they finally do get the approval, then
anyone with a bathtub can make the same product at a much cheaper price.
This is why dozens of products are available outside the USA and not here.
Murray Grossan, M.D.
http://www.ent-consult.com
Sue milham
2004-02-09 18:38:41 UTC
Permalink
I just got a refill for Mucofen 1000SA by Wakefield. My doc didn't seem to
know any different. I'll check with my pharmacist. I never seemed to do much
for me anyway and too long ingestion seemed to give me indigestion.

Don Brady ***@pobox.com wrote:
<< This one is more up to date:
http://www.af-pharmacists.org/safp/publications/recalls/mmqc_02_1351.htm
or

http://www.adamslaboratories.com/PRESS%20RELEASE%2010-21-02.pdf

Note the sentence:

"the FDA issued warning letters on October 11, 2002, deeming all extended
release guaifenesin tablets without an approved abbreviated new drug
application (ANDA) or NDA illegal and misbranded."


==================================================================

Adams Respiratory Therapeutics ANNOUNCES FDA APPROVAL OF NDA FOR 1200 mg
MUCINEX™ TABLET
- FDA Action Marks Company’s Second Product Approval for Long-Acting
Guaifenesin -

Fort Worth, TX – January 21, 2003 – Adams Respiratory Therapeutics, Inc., a
provider of specialty pharmaceuticals for respiratory care, today announced it
has received approval from the U.S. Food and Drug Administration (FDA) for its
new drug application (NDA) for the 1200 mg strength tablet of Mucinex™, a
single-entity, long-acting guaifenesin product that will be available without a
prescription. Mucinex™ provides the maximum therapeutic daily dosage of
guaifenesin for adults by taking one 1200 mg tablet, or two 600 mg tablets,
every 12 hours. It is indicated to help loosen phlegm (mucus) and thin
bronchial secretions to rid the bronchial passageways of bothersome mucus and
make coughs more productive.



The FDA approval of Mucinex™ 1200 mg is Adams Laboratories’ second product
approval in six months. In July of last year, the FDA approved the company’s
NDA for the Mucinex™ 600 mg tablet - the first long-acting guaifenesin
product
to have an NDA approved by the FDA. As a result of the Durham-Humphrey
Amendment of 1951 to the Federal Food, Drug, and Cosmetic Act which stipulates
that a drug product cannot be marketed simultaneously both as a prescription
and as a nonprescription product at the same strength and same dosage and for
the same indication, the FDA issued warning letters on October 11, 2002,
deeming all extended release guaifenesin tablets without an approved
abbreviated new drug application (ANDA) or NDA illegal and misbranded.





John Q. Adams Sr., Chairman and Chief Executive Officer, stated, “The FDA
approval of our Mucinex™ 1200 mg tablet marks Adams Respiratory
Therapeutics’
second major drug approval in the past several months, and demonstrates the
company’s ability to leverage our unique regulatory strategy and proprietary
technology to build a strong pipeline of respiratory products. Our large,
knowledgeable sales force will continue to aggressively market both the 600 mg
and 1200 mg Mucinex™ tablets to physicians and pharmacists in order to
capture
as much of the $3.2 billion cough, cold and flu market as possible. In
addition, we will continue to expand our respiratory franchise with NDA
submissions for Mucinex™ combination products this year.”



Mucinex™ is available “behind the counter” from pharmacists nationwide,
with or
without a physician’s recommendation. It works by loosening phlegm (mucus)
and
thinning bronchial secretions to rid the bronchial passageways of bothersome
mucus – making coughs more productive. Mucinex™ combines extended-release
and
immediate-release features in a single tablet.



ABOUT Adams Respiratory Therapeutics:

Based in Fort Worth, Texas, Adams Respiratory Therapeutics develops, markets
and sells prescription and non-prescription pharmaceuticals for the treatment
of respiratory disorders and diseases. In addition to Mucinex™, the Adams
Respiratory Therapeutics product portfolio includes the Aquatab® line of
guaifenesin-based cough and cold products and the ALLERx™ line of products to
treat allergic rhinitis. Adams Laboratories seeks to become the leading
specialty provider of pharmaceuticals for the treatment of a broad range of
respiratory diseases via a business development strategy that combines product
development, acquisitions and in-licensing tactics. More information can be
found on the company’s website at www.adamslaboratories.com. >><BR><BR>
Sue M.
j***@gmail.com
2018-01-31 13:15:03 UTC
Permalink
I agree this stuff doesn't work at all. Seems all the Rx that became over the counter or new improve shit is shit.
$
2018-08-10 17:19:02 UTC
Permalink
MS

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