‘Friendly bacteria’ may help prevent sinusitis

[AR Wingnutte]

‘Friendly bacteria’ may help prevent sinusitis
Published on September 21, 2012 at 9:15 AM · 1 Comment

inShare

By Helen Albert, Senior medwireNews Reporter

Having the right bacteria present in a person's sinuses might be key
to preventing chronic sinusitis, say researchers.

Reporting in Science Translational Medicine, the team found that the
microbial communities present in the sinuses of people with chronic
sinusitis and healthy controls differed significantly.

Sinusitis sufferers had a significantly greater proportion of
Corynebacterium tuberculostearicum than controls. Conversely, healthy
individuals appeared to have a greater number of Lactobacillus sakei
than sinusitis patients, which appeared to convey a protective effect.

"Presumably these are sinus-protective species," commented study
author Susan Lynch (University of California, San Francisco, USA) in a
press statement.

Lynch and colleagues recruited 10 patients with chronic sinusitis and
10 healthy controls to assess the composition of their sinus microbial
communities.

The researchers used comparative microbiome profiling to determine the
species and proportions of bacteria present in the sinuses of the
participants.

The chronic sinusitis patients had significantly reduced microbial
diversity compared with the controls. In particular there was a
notable decline in the numbers of multiple, phylogenetically distinct
lactic acid bacteria and a notable increase in the abundance of C.
tuberculostearicum.

Using a murine model, the researchers confirmed the pathogenic
potential of C. tuberculostearicum and showed that L. sakei, which was
present in significantly higher numbers in people without sinusitis,
is able to defend against sinus infection with C. tuberculostearicum,
even if other bacteria are depleted.

Sinusitis can be a difficult condition to treat, with antibiotics
commonly prescribed and sometimes even surgery. However, co-author
Andrew Goldberg, also from the University of California, commented
"the premise for our understanding of chronic sinusitis and
therapeutic treatment appears to be wrong, and a different therapeutic
strategy seems appropriate."

Our results "demonstrate that sinus mucosal health is highly dependent
on the composition of the resident microbiota as well as identify both
a new sinopathogen and a strong bacterial candidate for therapeutic
intervention," conclude the authors.

Licensed from medwireNews with permission from Springer Healthcare
Ltd. ©Springer Healthcare Ltd. All rights reserved. Neither of these
parties endorse or recommend any commercial products, services, or
equipment.

Be the first to rate this post
12345
Posted in: Medical Research News
Tags: Atrial Fibrillation, Lactobacillus, Medical Technical,
Sinusitis, Stroke, Thrombosis, Translational




http://www.news-medical.net/news/20120921/e28098Friendly-bacteriae28099-may-help-prevent-sinusitis.aspx

[Gene]

I thought the same thing when I read this: http://www.nytimes.com/2013/01/17/health/disgusting-maybe-but-treatment-works-study-finds.html. I thought, why not try to transplant healthy mucus. I even brought it up with my ENT, who probably LOL'ed a bit inside, but seemed receptive. What's the worst that can happen?

Post by AR Wingnutte
‘Friendly bacteria’ may help prevent sinusitis
Published on September 21, 2012 at 9:15 AM · 1 Comment
inShare
By Helen Albert, Senior medwireNews Reporter
Having the right bacteria present in a person's sinuses might be key
to preventing chronic sinusitis, say researchers.
Reporting in Science Translational Medicine, the team found that the
microbial communities present in the sinuses of people with chronic
sinusitis and healthy controls differed significantly.
Sinusitis sufferers had a significantly greater proportion of
Corynebacterium tuberculostearicum than controls. Conversely, healthy
individuals appeared to have a greater number of Lactobacillus sakei
than sinusitis patients, which appeared to convey a protective effect.
"Presumably these are sinus-protective species," commented study
author Susan Lynch (University of California, San Francisco, USA) in a
press statement.
Lynch and colleagues recruited 10 patients with chronic sinusitis and
10 healthy controls to assess the composition of their sinus microbial
communities.
The researchers used comparative microbiome profiling to determine the
species and proportions of bacteria present in the sinuses of the
participants.
The chronic sinusitis patients had significantly reduced microbial
diversity compared with the controls. In particular there was a
notable decline in the numbers of multiple, phylogenetically distinct
lactic acid bacteria and a notable increase in the abundance of C.
tuberculostearicum.
Using a murine model, the researchers confirmed the pathogenic
potential of C. tuberculostearicum and showed that L. sakei, which was
present in significantly higher numbers in people without sinusitis,
is able to defend against sinus infection with C. tuberculostearicum,
even if other bacteria are depleted.
Sinusitis can be a difficult condition to treat, with antibiotics
commonly prescribed and sometimes even surgery. However, co-author
Andrew Goldberg, also from the University of California, commented
"the premise for our understanding of chronic sinusitis and
therapeutic treatment appears to be wrong, and a different therapeutic
strategy seems appropriate."
Our results "demonstrate that sinus mucosal health is highly dependent
on the composition of the resident microbiota as well as identify both
a new sinopathogen and a strong bacterial candidate for therapeutic
intervention," conclude the authors.
Licensed from medwireNews with permission from Springer Healthcare
Ltd. ©Springer Healthcare Ltd. All rights reserved. Neither of these
parties endorse or recommend any commercial products, services, or
equipment.
Be the first to rate this post
12345
Posted in: Medical Research News
Tags: Atrial Fibrillation, Lactobacillus, Medical Technical,
Sinusitis, Stroke, Thrombosis, Translational
http://www.news-medical.net/news/20120921/e28098Friendly-bacteriae28099-may-help-prevent-sinusitis.aspx